Flavokawain B

CAS: 1775-97-9

Ref. BP-BP3146

Produktinformation

• Name: Flavokawain B
• Synonyme: (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one, (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one, (E)-1-(2-Hydroxy-4,6-Dimethoxy-Phenyl)-3-Phenyl-Propenone, (E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-, (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one, (E)-2′-Hydroxy-4′,6′-dimethoxychalcone, 1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-Phenyl-2-Propen-1-One), 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-, 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-, Cardamonin-4'-Methyl Ether, Chalcone, 2′-hydroxy-4′,6′-dimethoxy-, Dimethoxy-2'-Hydroxychalcone, 4',6'-, Flavokavain B, Flavokavin B, Flavokawin B, Persicochalcone

Beschreibung

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. Flavokawain B has potent anti-inflammatory, and anti-cancer activities, it can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

• Marke: Biopurify

Chemische Eigenschaften

• Molekulargewicht: 284.311
• Formel: C₁₇H₁₆O₄
• Reinheit: 95%~99%
• Farbe/Form: Yellow powder
• InChl: InChI=1S/C17H16O4/c1-20-13-10-15(19)17(16(11-13)21-2)14(18)9-8-12-6-4-3-5-7-12/h3-11,19H,1-2H3/b9-8+
• InChI Key: InChIKey=QKQLSQLKXBHUSO-CMDGGOBGSA-N
• SMILES: COc1cc(O)c(C(=O)/C=C/c2ccccc2)c(OC)c1