DAB2 rabbit pAb

Ref. EK-ES17027

Produktinformation

• Name: DAB2 rabbit pAb
• Synonyme: Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)

Beschreibung

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

• Marke: ELK Biotechnology