Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

Ref. EK-ES19956

Produktinformation

• Name: Caspase 4 (p10, Cleaved-Ala290) rabbit pAb
• Synonyme: Caspase-4 (CASP-4;EC 3.4.22.57;ICE(rel)-II;Protease ICH-2;Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]

Beschreibung

catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit.,tissue specificity:Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.,

• Marke: ELK Biotechnology