Bavisant dihydrochloride hydrate

CAS: 1103522-80-0

Ref. TM-T10462L

Produktinformation

• Name: Bavisant dihydrochloride hydrate
• Synonyme: JNJ31001074AAC
• CAS: 1103522-80-0

Beschreibung

Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. in vivo: Mean change from baseline in the total ADHD-RS-IV score at day 42 (primary efficacy endpoint) was -8.8 in the placebo group versus -9.3, -11.2 and -12.2 in the bavisant 1 mg/day, 3 mg/day and 10 mg/day groups, respectively; the change in the 10 mg/day group was not statistically superior to placebo (p=0.161). IC50 Value: Target: H3 receptor in vitro: Bavisant completed a phase II ADHD trial, but no results have been reported [1]. And hence statistical comparisons of the 1 mg/day and 3 mg/day groups with placebo based on a step-down closed testing procedure were not performed [2]. Clinical trial: A Study to Characterize the Pharmacokinetics and Effect of Food on JNJ-31001074 in Healthy Volunteers. Phase 2

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 420.38
• Formel: C₁₉H₃₁Cl₂N₃O₃