CHMFL-PI3KD-317

CAS: 2244992-76-3

Ref. TM-T10804

Produktinformation

• Name: CHMFL-PI3KD-317
• CAS: 2244992-76-3

Beschreibung

CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 494.03
• Formel: C₂₁H₂₄ClN₅O₃S₂
• Reinheit: 97.8%
• Farbe/Form: Solid