EN6

CAS: 1808714-73-9

Ref. TM-T11191

Produktinformation

• Name: EN6
• Synonyme: EN-6
• CAS: 1808714-73-9

Beschreibung

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 368.34
• Formel: C₁₉H₁₄F₂N₄O₂
• Reinheit: 97.04%
• Farbe/Form: Solid