Nadolol

CAS: 42200-33-9

Ref. TM-T1203

Produktinformation

• Name: Nadolol
• Synonyme: Anabet, Corgard, Solgol, SQ11725, (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol, 1-(tert-Butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2-propanol, 2,3-Naphthalenediol, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-, cis-, 2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-, 2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol, 5-(3-((1,1-Dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-2,3-naphthalenediol, 5-[3-(Tert-Butylamino)-2-Hydroxypropoxy]-1,2,3,4-Tetrahydronaphthalene-2,3-Diol, Anabet, Ccris 1048, Corgard, Corzide, Hsdb 6532, Nadolol [USAN:INN:BAN:JAN], Nadololum, Nadololum [INN-Latin], Solgol, Sq 11725, Unii-Fen504330V

Beschreibung

Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 309.4
• Formel: C₁₇H₂₇NO₄
• Reinheit: 99.92%
• Farbe/Form: White To Off-White Crystalline Powder Solid