A-192621

CAS: 195529-54-5

Ref. TM-T14068

Produktinformation

• Name: A-192621
• Marke: Targetmol
• Beschreibung: A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).

Chemische Eigenschaften

• Molekulargewicht: 558.66
• Formel: C₃₃H₃₈N₂O₆
• Reinheit: 98%
• Farbe/Form: Solid