Apricitabine

CAS: 160707-69-7

Ref. TM-T14313

Produktinformation

• Name: Apricitabine
• Synonyme: AVX754, SPD754, (-)-2′-Deoxy-3′-oxa-4′-thiocytidine, (-)-Bch 10652, 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv., 2(1H)-Pyrimidinone, 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-, 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-, (2R-cis)-, 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone, Avx 754, Bch 10618, Spd 754
• CAS: 160707-69-7

Beschreibung

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 229.26
• Formel: C₈H₁₁N₃O₃S
• Reinheit: 100%
• Farbe/Form: Solid