BMS-906024

CAS: 1401066-79-2

Ref. TM-T14680

Produktinformation

• Name: BMS-906024
• Synonyme: Osugacestat, AL-101, BM-0018

Beschreibung

BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 556.5
• Formel: C₂₆H₂₆F₆N₄O₃
• Reinheit: 100%
• Farbe/Form: Solid