NS-2028

CAS: 204326-43-2

Ref. TM-T16344

Produktinformation

• Name: NS-2028
• Synonyme: NS2028, 1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-, 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)ben(b)(1,4)oxazin-1-one, 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one, Ns 2028
• CAS: 204326-43-2

Beschreibung

NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase (IC50: 17 nM and 20 nM). NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells (IC50: 30 nM). NS-2028 inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 decreases vascular endothelial growth factor-induced angiogenesis and permeability.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 269.05
• Formel: C₉H₅BrN₂O₃
• Reinheit: 99.44%
• Farbe/Form: A Crystalline Solid