8-Chloroadenosine

CAS: 34408-14-5

Ref. TM-T19661

Produktinformation

• Name: 8-Chloroadenosine
• Synonyme: NSC 354258, 8-Cl-Ado, NSC354258, NSC-354258
• CAS: 34408-14-5

Beschreibung

8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Chloroadenosine (NSC-354258) is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226, and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. 8-Chloroadenosine (NSC-354258) has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 301.69
• Formel: C₁₀H₁₂ClN₅O₄
• Reinheit: 99.48%
• Farbe/Form: Solid