ES-072

CAS: 2089721-94-6

Ref. TM-T200087

Produktinformation

• Name: ES-072
• Marke: Targetmol
• Beschreibung: ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.

Chemische Eigenschaften

• Molekulargewicht: 528.53
• Formel: C₂₅H₂₇F₃N₈O₂
• Farbe/Form: Solid