hURAT1 inhibitor 1

Ref. TM-T200163

Produktinformation

• Name: hURAT1 inhibitor 1
• Marke: Targetmol
• Beschreibung: Compound 27b, also known as hURAT1 inhibitor 1, is an isomarine-derived, orally active inhibitor that targets both hURAT1 and GLUT9 with IC50 values of 0.16 μM and 4.47 μM, respectively. This compound exhibits significant anti-hyperuricemia effects and has demonstrated potent uric acid-lowering activity in a hyperuricemia mouse model at a dose of 10 mg/kg. Importantly, Compound 27b displays no notable in vitro cytotoxicity or in vivo hepatotoxicity, and possesses favorable pharmacokinetic (PK) characteristics.

Chemische Eigenschaften

• Molekulargewicht: 451.31
• Formel: C₂₄H₁₉BrO₄