Cernuumolide J

CAS: 2019163-02-9

Ref. TM-T200239

Produktinformation

• Name: Cernuumolide J
• Synonyme: TMJ-105

Beschreibung

Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 μM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 450.52
• Formel: C₂₄H₃₄O₈
• Farbe/Form: Liquid