FOXJ1 agonist 1

Ref. TM-T200312

Produktinformation

• Name: FOXJ1 agonist 1
• Marke: Targetmol
• Beschreibung: FOXJ1 agonist 1 (compound 16c), an orally effective small molecule, effectively enhances FOXJ1 expression and acts on multiciliated cells (MCC) in the mammalian airway system to prevent chronic obstructive pulmonary disease (COPD). Foxj1-IN-1 induces motile cilia production in the respiratory system of both zebrafish and mammals and inhibits elastase-induced COPD in mouse models. Additionally, Foxj1-IN-1 demonstrates good liver microsomal stability and favorable in vivo pharmacokinetic (PK) curves and area under the curve (AUC). It exhibits negligible inhibition of CYP and hERG and lacks significant cytotoxicity.

Chemische Eigenschaften

• Molekulargewicht: 433.5
• Formel: C₂₄H₂₇N₅O₃
• Farbe/Form: Solid