Tubulin polymerization-IN-76

Ref. TM-T205237

Produktinformation

• Name: Tubulin polymerization-IN-76
• Marke: Targetmol
• Beschreibung: Tubulin polymerization-IN-76 (compound 20b) is a potent and orally active inhibitor of tubulin polymerization. It acts at the colchicine binding site to inhibit tubulin polymerization with an IC50 value of 2.505 μM, effectively disrupting the intracellular microtubule network and interfering with mitosis. Tubulin polymerization-IN-76 shows significant inhibitory effects on MGC-803 and HGC-27 cells, with IC50 values of 1.61 and 1.82 nM, respectively. It effectively suppresses colony formation and cell migration activities in these cell lines, inducing G2/M phase cell cycle arrest and apoptosis (Apoptosis). Furthermore, Tubulin polymerization-IN-76 exhibits broad-spectrum antiproliferative activity.

Chemische Eigenschaften

• Molekulargewicht: 363.48
• Formel: C₂₀H₂₁N₅S
• Farbe/Form: Solid