Menin-KMT2A-IN-1

Ref. TM-T205488

Produktinformation

• Name: Menin-KMT2A-IN-1
• Marke: Targetmol
• Beschreibung: Menin–KMT2A-IN-1 (Compound 20) is an inhibitor of menin–KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin–KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.

Chemische Eigenschaften

• Molekulargewicht: 522.61
• Formel: C₂₈H₃₅FN₆O₃
• Farbe/Form: Solid