Nitric oxide production-IN-2

CAS: 1019984-44-1

Ref. TM-T206206

Produktinformation

• Name: Nitric oxide production-IN-2
• Marke: Targetmol
• Beschreibung: TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.

Chemische Eigenschaften

• Molekulargewicht: 344.403
• Formel: C₂₃H₂₀O₃
• Farbe/Form: Solid