5-Hydroxy-1-methylhydantoin

CAS: 84210-26-4

Ref. TM-T28222

Produktinformation

• Name: 5-Hydroxy-1-methylhydantoin
• Synonyme: HD-003, HD003, NZ419, NZ-419, HD 003, NZ 419
• CAS: 84210-26-4

Beschreibung

5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 130.1
• Formel: C₄H₆N₂O₃
• Reinheit: 99.50%
• Farbe/Form: Solid