Bardoxolone

CAS: 218600-44-3

Ref. TM-T2915

Produktinformation

• Name: Bardoxolone
• Synonyme: RTA 401, CDDO, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid
• CAS: 218600-44-3

Beschreibung

Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis. In various Y cell lines, Bardoxolone has been shown to specifically inhibit proliferation and induce apoptosis. Mechanism studies revealed that Bardoxolone is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 491.66
• Formel: C₃₁H₄₁NO₄
• Reinheit: 99.19%
• Farbe/Form: Solid