S49076 HCl

CAS: 1265966-31-1

Ref. TM-T3512

Produktinformation

• Name: S49076 HCl
• Synonyme: S-49076 Hydrochloride
• CAS: 1265966-31-1

Beschreibung

S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 HCl potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 HCl inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 HCl was established and correlated well with impact on tumor growth.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 439.85
• Formel: C₂₂H₁₈ClN₃O₅
• Reinheit: 98%
• Farbe/Form: Solid