Setipiprant

CAS: 866460-33-5

Ref. TM-T3520

Produktinformation

• Name: Setipiprant
• Synonyme: KYTH-105, ACT-129968
• CAS: 866460-33-5

Beschreibung

Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 402.42
• Formel: C₂₄H₁₉FN₂O₃
• Reinheit: 99.71%
• Farbe/Form: Solid