LDN-193189 2HCl

CAS: 1435934-00-1

Ref. TM-T35348

Produktinformation

• Name: LDN-193189 2HCl
• Synonyme: LDN-193189 2HCl, DM-3189 2HCl
• CAS: 1435934-00-1

Beschreibung

LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively. LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors ALK2 and ALK3 in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively, and was 200-fold more selective for BMP than for TGF-β.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 479.4
• Formel: C₂₅H₂₄Cl₂N₆
• Reinheit: 99.78%
• Farbe/Form: Solid