Entrectinib

CAS: 1108743-60-7

Ref. TM-T3678

Produktinformation

• Name: Entrectinib
• Synonyme: RXDX-101, NMS-E628
• CAS: 1108743-60-7

Beschreibung

Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with C1156Y or L1196M resistance mutations, and inhibits ALK-dependent signaling. It has been shown to inhibit the growth of a non-small cell lung Y cell line bearing an EML4-ALK rearrangement. In mice bearing various ROS1, Trk, or ALK-driven xenografts, Entrectinib has been shown to induce tumor regression.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 560.64
• Formel: C₃₁H₃₄F₂N₆O₂
• Reinheit: 99.61%
• Farbe/Form: Solid