4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt)

CAS: 206443-06-3

Ref. TM-T37566

Produktinformation

• Name: 4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt)

Beschreibung

4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity. 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient. 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 441.36
• Formel: C₁₆H₁₈NaO₁₁S