Juglone

CAS: 481-39-0

Ref. TM-T4010

Produktinformation

• Name: Juglone
• Synonyme: 5-Hydroxy-1,4-naphthoquinone, Regianin, 1,4-Dihydro-1,4-dioxo-5-hydroxynaphthalene, 1,4-Naphthalenedione, 5-hydroxy-, 1,4-Naphthoquinone, 5-hydroxy-, 5-Hidroxi-1,4-Naftoquinona, 5-Hydrocy-1,4-Naphthoquinone, 5-Hydroxy-1,4-naphthalenedione, 5-Hydroxy-1,4-naphthochinon, 5-Hydroxy-1,4-naphthoquinone, 5-Hydroxy-1,4-naphtoquinone, 5-Hydroxynaphthalene-1,4-Dione, 5-Hydroxynaphthoquinone, 8-Hydroxy-1,4-naphthoquinone, Akhnot, Juglon, Natural Brown 7, Nsc 153189, Nsc 34266, Nsc 622948, Nucin, Regianin, Walnut Extract
• CAS: 481-39-0

Beschreibung

Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 174.15
• Formel: C₁₀H₆O₃
• Reinheit: 98.73%
• Farbe/Form: Red Powder
• InChl: InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H
• InChI Key: InChIKey=KQPYUDDGWXQXHS-UHFFFAOYSA-N
• SMILES: O=C1C=CC(=O)c2c(O)cccc21