CBL0137

CAS: 1197996-80-7

Ref. TM-T4126

Produktinformation

• Name: CBL0137
• Synonyme: Curaxin 137, CBLC137
• CAS: 1197996-80-7

Beschreibung

CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 336.43
• Formel: C₂₁H₂₄N₂O₂
• Reinheit: 98%
• Farbe/Form: Solid