Capmatinib 2HCl

CAS: 1197376-85-4

Ref. TM-T4260

Produktinformation

• Name: Capmatinib 2HCl
• Synonyme: INC-280 2HCl, INCB28060 2HCl
• CAS: 1197376-85-4

Beschreibung

Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 485.34
• Formel: C₂₃H₁₉Cl₂FN₆O
• Reinheit: 100%
• Farbe/Form: Solid