RO1138452

CAS: 221529-58-4

Ref. TM-T4436

Produktinformation

• Name: RO1138452
• Synonyme: CAY10441, Cay 10441, Ro 1138452

Beschreibung

RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 309.41
• Formel: C₁₉H₂₃N₃O
• Reinheit: 99.34%
• Farbe/Form: Solid