Sulfaphenazole

CAS: 526-08-9

Ref. TM-T4567

Produktinformation

• Name: Sulfaphenazole
• Synonyme: Plisulfan, Raziosulfa, Depocid, Depotsulfonamide, 1-Phenyl-5-sulfanilamidopyrazole, 2-Phenyl-3-sulfanilamidopyrazole, 3-(p-Aminobenzenesulfonamido)-2-phenylpyrazole, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide, 5-Sulfanilamido-1-phenylpyrazole, Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-, Depocid, Depotsulfonamide, Eftolon, Firmazolo, Inamil, Isarol, Isarol V, Merian, Microtan pirazolo, N1-(1-phenylpyrazol-5-yl)sulphanilamide, N¹-(1-Phenylpyrazol-5-yl)sulfanilamide, Orisul, Orisulf, Paidazolo, Plisulfan, Raziosulfa, Sulfabid, Sulfanilamide, N¹-(1-phenylpyrazol-5-yl)-, Sulfaphenazol, Sulfaphenazon, Sulfaphenylpyrazole, Sulphaphenazole
• CAS: 526-08-9

Beschreibung

Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 314.36
• Formel: C₁₅H₁₄N₄O₂S
• Reinheit: 99.67%
• Farbe/Form: Solid