NS309

CAS: 18711-16-5

Ref. TM-T4612

Produktinformation

• Name: NS309
• Synonyme: NS-309, 1H-Indole-2,3-dione, 6,7-dichloro-, 3-oxime, 6,7-Dichloro-1H-indole-2,3-dione 3-oxime, 6,7-Dichloroisatin 3-oxime, Indole-2,3-dione, 6,7-dichloro-, 3-oxime, Ns 309, Ns309
• CAS: 18711-16-5

Beschreibung

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 231.04
• Formel: C₈H₄Cl₂N₂O₂
• Reinheit: 95.87%
• Farbe/Form: Solid