WHI-P97

CAS: 211555-05-4

Ref. TM-T4657

Produktinformation

• Name: WHI-P97
• Synonyme: WHI-P-97
• CAS: 211555-05-4

Beschreibung

WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 455.1
• Formel: C₁₆H₁₃Br₂N₃O₃
• Reinheit: 98.91%
• Farbe/Form: Solid