4-​Hydroxyphenylpyruvic acid

CAS: 156-39-8

Ref. TM-T4858

Produktinformation

• Name: 4-​Hydroxyphenylpyruvic acid
• Synonyme: (p-Hydroxyphenyl)pyruvic acid, 3-(4-Hydroxyphenyl)-2-Oxopropanoate, 3-(4-Hydroxyphenyl)-2-Oxopropanoic Acid, 3-(4-Hydroxyphenyl)-2-oxopropionic acid, 3-(p-Hydroxyphenyl)-2-oxopropanoic acid, 3-(p-Hydroxyphenyl)-2-oxopropionic acid, 3-(p-Hydroxyphenyl)pyruvic acid, 4-Hydroxy alpha-oxobenzenepropanoic acid, 4-Hydroxy-α-oxobenzenepropanoic acid, Benzenepropanoic acid, 4-hydroxy-alpha-oxo- (9CI), Benzenepropanoic acid, 4-hydroxy-α-oxo-, Brn 2691632, NSC 666757, Nsc 100738, Pyruvic acid, p-hydroxyphenyl-, Testacid, Testacide, p-Hydroxyphenylpyruvic acid, ；3-(4-Hydroxyphenyl)pyruvic acid
• CAS: 156-39-8

Beschreibung

4-Hydroxyphenylpyruvic acid is an enzyme inhibitor.4-Hydroxyphenylpyruvic acid (4-HPPA) is a keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase (EC 1.1.1.222) and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. The enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPD) catalyzes the reaction that converts 4-hydroxyphenylpyruvic acid to homogentisic acid. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine. It has been shown that hawkinsinuria, an autosomal dominant disorder characterized by the excretion of 'hawkinsin,' may also be a result of HPD deficiency . Moreover, 4-hydroxyphenylpyruvic acid is also found to be associated in phenylketonuria, which is also an inborn error of metabolism. There are two isomers of HPPA, specifically 4HPPA and 3HPPA, of which 4HPPA is the most common.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 180.16
• Formel: C₉H₈O₄
• Reinheit: 97.56%
• Farbe/Form: Solid