Glaucocalyxin A

CAS: 79498-31-0

Ref. TM-T4S0498

Produktinformation

• Name: Glaucocalyxin A
• Synonyme: Wangzaozin B, Leukamenin F, (5Beta,7Alpha,9Beta,10Alpha)-7,14-Dihydroxykaur-16-Ene-3,15-Dione, (7α,14R)-7,14-Dihydroxykaur-16-ene-3,15-dione, 7H-2,10a-Ethanophenanthrene, kaur-16-ene-3,15-dione deriv., Kaur-16-ene-3,15-dione, 7,14-dihydroxy-, (7α,14R)-, Leucamenin F, Wangzaozin B, leukamenin F
• CAS: 79498-31-0

Beschreibung

1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 332.43
• Formel: C₂₀H₂₈O₄
• Reinheit: 99.56%
• Farbe/Form: Solid