Cornuside
CAS: 131189-57-6
Ref. TM-T4S2326
1mg | 94,00 € | ||
5mg | 259,00 € | ||
10mg | 409,00 € | ||
25mg | 662,00 € | ||
50mg | 915,00 € | ||
100mg | 1.230,00 € | ||
500mg | 2.471,00 € | ||
1ml*10 (DMSO) | 328,00 € |
Produktinformation
- 7-Galloylsecologanol, 7-O-Galloylsecologanol, Comuside
- 2H-Pyran-5-carboxylic acid, 3-ethenyl-2-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-3,4-dihydro-4-[2-[(3,4,5-trihydroxybenzoyl)oxy]ethyl]-, methyl ester, (2S,3R,4S)-
- 2H-Pyran-5-carboxylic acid, 3-ethenyl-2-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-3,4-dihydro-4-[2-[(3,4,5-trihydroxybenzoyl)oxy]ethyl]-, methyl ester, [2S-(2α,3β,4β)]-
- Cornuside I
- Methyl (2R,3S,4R)-3-ethenyl-4-[2-(3,4,5-trihydroxybenzoyl)oxyethyl]-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate
- methyl (2R,3S,4R)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-4-{2-[(3,4,5-trihydroxybenzoyl)oxy]ethyl}-3,4-dihydro-2H-pyran-5-carboxylate
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
Chemische Eigenschaften
Technische Anfrage zu: TM-T4S2326 Cornuside
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