N1,N11-Diethylnorspermine

CAS: 121749-39-1

Ref. TM-T60348

Produktinformation

• Name: N1,N11-Diethylnorspermine
• Synonyme: 1,3-Propanediamine N1,N3-bis[3-(ethylamino)propyl]-, 1,3-Propanediamine, N,N′-bis[3-(ethylamino)propyl]-, 1,3-Propanediamine, N¹,N³-bis[3-(ethylamino)propyl]-, Be 3-3-3, Be 333, Be3-3-3, Benspm, De 333, De333, Denspm, Diethyl-norspermine, Diethylnorspermine, N(1),N(11)-Diethylnorspermine, N(Sup1),N(Sup11)-Bis(Ethyl)Norspermine, N(Sup1),N(Sup11)-Diethylnorspermine, N,N'-Bis(3-(Ethylamino)Propyl)-3-Propanediamine, N¹,N¹¹-Bis(ethyl)norspermine, N¹,N¹¹-Diethylnorspermine, N¹,N³-Bis[3-(ethylamino)propyl]-1,3-propanediamine, N~1~,N~1~'-propane-1,3-diylbis(N~3~-ethylpropane-1,3-diamine)

Beschreibung

N1,N11-Diethylnorspermine (DENSPM), a spermine analog, serves as a potent anticancer agent by activating polyamine catabolism, which in turn triggers cytochrome c release from mitochondria and activates caspase 3. This process ultimately leads to the death of glioblastoma multiforme (GBM) cells by inducing spermidine/spermine N1-acetyltransferase (SSAT) activity along with the production of H2O2 [1] [2] [3].

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 244.42
• Formel: C₁₃H₃₂N₄