Buclizine dihydrochloride

CAS: 129-74-8

Ref. TM-T6426

Produktinformation

• Name: Buclizine dihydrochloride
• Synonyme: Longifene, Buclina, Buclizine HCl, UCB-4445, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride, 1-(4-Tert-Butylbenzyl)-4-[(4-Chlorophenyl)(Phenyl)Methyl]Piperazine Dihydrochloride, 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine hydrochloride, 1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride, 1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride, Aphilan R, Bucladin S, Buclina, Buclizine HCl, Buclizine Hydrochloride, Buclodin, Histabutyzine hydrochloride, Longifene, NSC 25141, Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-, dihydrochloride, Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, dihydrochloride, Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2), Softran, Ucb 4445, Vibazine, Vibazine Hydrochloride
• CAS: 129-74-8

Beschreibung

Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine dihydrochloride exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 505.95
• Formel: C₂₈H₃₃ClN₂·2HCl
• Reinheit: 99.56%
• Farbe/Form: Off-White Powder