Galeterone

CAS: 851983-85-2

Ref. TM-T6509

Produktinformation

• Name: Galeterone
• Synonyme: VN-124-1, TOK-001, VN/124-1, VN 124, (3beta)-17-(1H-BenziMidazol-1-yl)androsta-5,16-dien-3-ol, (3β)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol, Androsta-5,16-dien-3-ol, 17-(1H-benzimidazol-1-yl)-, (3β)-, Galaterone, Tk-001, Tok 001, Vn 124, Vn/124-1
• CAS: 851983-85-2

Beschreibung

Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17, 20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 388.55
• Formel: C₂₆H₃₂N₂O
• Reinheit: 99.773%
• Farbe/Form: Solid