NSC697923

CAS: 343351-67-7

Ref. TM-T6611

Produktinformation

• Name: NSC697923
• Synonyme: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
• CAS: 343351-67-7

Beschreibung

NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 267.26
• Formel: C₁₁H₉NO₅S
• Reinheit: 99.69%
• Farbe/Form: Solid