Oroxylin A

CAS: 480-11-5

Ref. TM-T6S1315

Produktinformation

• Name: Oroxylin A
• Synonyme: 6-Methoxybaicalein, Baicalein 6-methyl ether, 4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-, 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one, 6-Methoxybaicalein, Baicalein 6-methyl ether, Flavone, 5,7-dihydroxy-6-methoxy-, Oroxylin, oroxylin A
• CAS: 480-11-5

Beschreibung

1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 284.26
• Formel: C₁₆H₁₂O₅
• Reinheit: 99.67%
• Farbe/Form: Solid