TWIK-1/TREK-1-IN-1

CAS: 1440532-30-8

Ref. TM-T78868

Produktinformation

• Name: TWIK-1/TREK-1-IN-1
• CAS: 1440532-30-8

Beschreibung

Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as an antidepressant target. Furthermore, TWIK-1/TREK-1-IN-3, a related compound, selectively inhibits these channels with IC50 values of 9.36 μM for TREK-1 homodimers and 14.6 μM for TWIK-1/TREK-1 heterodimers, demonstrating antidepressant-like effects [1].

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 395.42
• Formel: C₂₁H₂₄F₃NO₃
• Reinheit: 98%