mHTT-IN-2

CAS: 2743336-70-9

Ref. TM-T79717

Produktinformation

• Name: mHTT-IN-2

Beschreibung

mHTT-IN-2 (compound 27) is a potent inhibitor of mutant huntingtin protein (mHTT), with an EC50 value of 0.066 μM. It specifically modulates the splicing of HTT RNA exons [49-50], acting as a splicing regulator for the HTT gene. Demonstrating inhibitory effects both in vitro and in vivo, mHTT-IN-2 has been tested in human HD stem cells and mouse BACHD models. Additionally, it is applicable in the investigation of branaplam-related peripheral neuropathy [1].

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 395.43
• Formel: C₂₀H₂₂FN₇O
• Reinheit: 98%