TNO211

CAS: 193475-71-7

Ref. TM-T80242

Produktinformation

• Name: TNO211
• Synonyme: Dabcyl-(Gamma-Abu)-Pqgl-E(Edans)Ak-Nh2, Dabcyl-Gamma-Abu-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-Nh2, Dabcyl-Gaba-Pqgl-E(Edans)-Ak-Nh2, Dabcyl-Gaba-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-Nh2, Dabcyl-(G-Abu)-Pqgl-E(Edans)Ak-Nh2, Dabcyl-(G-Abu)-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-Nh2, Tno211
• CAS: 193475-71-7

Beschreibung

TNO211 is a bioactive peptide that functions as a highly soluble fluorogenic substrate for select Matrix Metalloproteinases (MMPs)-specifically MMP-2, 8, 12, 13, and 14. Incorporating a cleavable Gly-Leu bond and an EDANS/DABCYL fluorophore/quencher pair, TNO211 enables sensitive detection of MMP activity through fluorescence assays, with an absorption/emission profile at 340/490 nm. It is particularly effective in analyzing MMPs in culture media from endothelial cells as well as untreated synovial fluid from patients, highlighting its utility in investigations of MMP-associated cellular behaviors, including proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 1325.54
• Formel: C₆₃H₈₈N₁₆O₁₄S
• Reinheit: 98%