5'-Ethynyl-2'-deoxycytidine

CAS: 69075-47-4

Ref. TM-T84380

Produktinformation

• Name: 5'-Ethynyl-2'-deoxycytidine
• Synonyme: EdC, Click Tag™ 5'-Ethynyl-2'-deoxycytidine, 2'-deoxy-5-Ethynylcytidine
• Marke: Targetmol
• Beschreibung: 5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively). Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.

Chemische Eigenschaften

• Molekulargewicht: 251.242
• Formel: C₁₁H₁₃N₃O₄
• Farbe/Form: Solid