Cdk4 Inhibitor

CAS: 546102-60-7

Ref. TM-T84413

Produktinformation

• Name: Cdk4 Inhibitor
• Synonyme: Cyclin-dependent kinase 4 Inhibitor
• Marke: Targetmol
• Beschreibung: PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.

Chemische Eigenschaften

• Molekulargewicht: 404.2
• Formel: C₂₀H₁₀BrN₃O₂
• Farbe/Form: Solid