5(S)-HEPE

CAS: 92008-51-0

Ref. TM-T84567

Produktinformation

• Name: 5(S)-HEPE
• Synonyme: (5S,6E,8Z,11Z,14Z,17Z)-5-Hydroxy-6,8,11,14,17-eicosapentaenoic acid, 5-Hepe, 5-Hydroxyeicosapentaenoic acid, 6,8,11,14,17-Eicosapentaenoic acid, 5-hydroxy-, (5S,6E,8Z,11Z,14Z,17Z)-, 6,8,11,14,17-Eicosapentaenoic acid, 5-hydroxy-, [S-(E,Z,Z,Z,Z)]-, 92008-51-0

Beschreibung

5(S)-HEPE, an active metabolite of eicosapentaenoic acid (EPA), is produced via the action of 5-lipoxygenase (5-LO). This compound functions as an agonist for G protein-coupled receptor 119 (GPR119), promoting cAMP accumulation in CHO-K1 cells expressing human GPR119 at 10 µM concentration. Additionally, 5(S)-HEPE enhances glucose-stimulated insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells at the same concentration. Notably, serum levels of 5(S)-HEPE are increased in hyperlipidemia patients.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 318.5
• Formel: C₂₀H₃₀O₃
• Farbe/Form: Solid