5α-Androstan-3β-ol

CAS: 1224-92-6

Ref. TM-T84963

Produktinformation

• Name: 5α-Androstan-3β-ol
• Synonyme: NSC 50887, (3Beta,5Alpha)-Androstan-3-Ol, (3β,5α)-Androstan-3-ol, 3beta-Hydroxy-5alpha-androstane, 3β-Hydroxy-5α-androstane, 5alpha-Androstan-3beta-ol, Androstan-3-ol, Androstan-3-ol, (3beta,5alpha)- (9CI), Androstan-3-ol, (3β,5α)-, Nsc 50887

Beschreibung

5α-Androstan-3β-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 µM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 µM. It selectively inhibits the hydroxylase activities of 16α- and 6β-hydroxylase over 16β- or 7α-hydroxylase, with IC50 values of 70 and 110 µM, compared to >150 µM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 276.46
• Formel: C₁₉H₃₂O
• Farbe/Form: Solid