4-Methylumbelliferyl-α-D-Glucopyranoside

CAS: 17833-43-1

Ref. TM-T85134

Produktinformation

• Name: 4-Methylumbelliferyl-α-D-Glucopyranoside
• Synonyme: 4-Methylumbelliferyl-α-D-Glucoside, 4-Methylumbelliferyl-α-D-Glucose, 4-MU-α-D-Glucopyranoside, 2H-1-Benzopyran-2-one, 7-(α-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-4-methyl-, 4-Methylumbelliferyl A-D-Glucopyranoside, 4-Methylumbelliferyl α-<span class="text-smallcaps">D</span>-glucopyranoside, 4-Methylumbelliferyl α-<span class="text-smallcaps">D</span>-glucose, 4-Methylumbelliferyl α-<span class="text-smallcaps">D</span>-glucoside, 4-Methylumbelliferyl-A-D-Glucoside, 4-Methylumbelliferyl-Alpha-D-Glucopyranoside, 4-Methylumbelliferyl-Alpha-D-Glucoside, 4-Mu-Alpha-D-Glc, 4-methyl-2-oxo-2H-chromen-7-yl alpha-D-glucopyranoside, 4-methyl-2-oxo-2H-chromen-7-yl alpha-L-galactopyranoside, 7-(alpha.-D-glucopyranosyloxy)-4-methyl-2H-1-Benzopyran-2-one, 7-(α-<span class="text-smallcaps">D</span>-Glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one, 7-Hydroxy-4-Methylcumarin-Alpha-D-Glucopyranosid, Coumarin, 7-(α-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-4-methyl-

Beschreibung

4-Methylumbelliferyl-α-D-glucopyranoside serves as a fluorogenic substrate for α-glucosidase, used in enzymatic assays. This compound undergoes cleavage by α-glucosidase, releasing 4-methylumbelliferyl (4-MU), a compound whose fluorescence intensity varies with pH. Specifically, 4-MU exhibits excitation peaks at 320 nm and 360 nm in acidic (pH 1.97-6.72) and alkaline environments (pH 7.12-10.3), respectively, and its emission peak ranges between 445 nm and 455 nm, with brightness increasing as the pH drops. Utilizing these properties, 4-Methylumbelliferyl-α-D-glucopyranoside has been effectively applied in the measurement of α-glucosidase activity within infant blood spot samples, acting as a diagnostic marker for Fabry and Pompe diseases. These illnesses are types of lysosomal storage disorders caused by α-glucosidase enzyme deficiency.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 338.312
• Formel: C₁₆H₁₈O₈