(S)-3'-amino Blebbistatin

CAS: 2097141-18-7

Ref. TM-T85257

Produktinformation

• Name: (S)-3'-amino Blebbistatin
• Synonyme: meta-amino Blebbistatin, m-amino Blebbistatin, (−)-3'-amino Blebbistatin

Beschreibung

"(S)-3'-amino Blebbistatin, retaining the active stereochemistry of the less stable and more phototoxic (-)-blebbistatin, serves as a refined selective cell-permeable inhibitor of non-muscle myosin II ATPases. This compound efficaciously inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across several species with IC50s ranging from 0.5-5 µM, and exhibits minimal inhibition against smooth muscle myosin (IC50= 80 µM). Its primary functions include obstructing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. (S)-3'-amino Blebbistatin overcomes (-)-blebbistatin’s limitation of rapid degradation under blue light (450-490 nm) exposure, which generates cytotoxic intermediates, thus posing a challenge for fluorescent live cell imaging applications. The introduction of a 3’-amino group to its structure notably reduces fluorescence while maintaining (-)-blebbistatin’s activity, making it a superior alternative for research purposes."

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 307.35
• Formel: C₁₈H₁₇N₃O₂
• Farbe/Form: Solid